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KMID : 0378019990420090056
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New Medical Journal
1999 Volume.42 No. 9 p.56 ~ p.66
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Effect of Burn Injury on Immune Responses and Interleukin-6 Production in Mice
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김금재/Kum Jae Kim
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Abstract
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-Abstract-
With a murine model of bum injury involving second degree burn of 30% of the total
body surface area, effect of burn injury on the humoral and cellular immune responses
and the production of IL-6 by splenocyte of the burned mice was alsd determined. The
humoral responses such as antibody response to a thymus-independent antigen, sheep
red blood cells(SRBC) and a thymus-independent antigen, polyvinylpyrroridone(PVP) and
cellular immune responses, such as delayed-type hypersensitivity(DTH) to SRBC and
contact hypersensitivity to dinitrofluorobenzene (DNFB) were examined 7 days after
burn injury. It was interestingly demonstrated that the humoral and cellular immune
responses of burned mice were severly depressed, but the production of IL-6 by
splenocytes of burned mice were increased. Taken together, the present data strongly
suggest that burn injury may enhance IL-6 production, but suppress the humoral and
cellular immune responses.
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KEYWORD
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